We investigated the prevalence rate of HPV DNAs in normal mucosa in the oral region. The nested PCR method was utilized to detect target DNA sequences using HPV E6/E7 consensus primer pairs. Of 56 patients examined, HPV 6 and HPV 16 DNA sequences were detected in a 46-year-old male and a 35-year-old female, respectively. These results suggest that HPVs are uncom-mon in normal oral epithelium, and that we should carry out careful follow-up in HPV DNA-positive cases
