Kiliç, M.

Kiraç, F.S.

Serdaş, T.

Yaylalı, Olga

Yüksel, Doğangün

Pamukkale Üniversitesi Açık Erişim Arşivi

140
Non-cardiac Tl-201 uptake on myocardial 
perfusion SPECT study
Miyokard perfüzyon SPECT çal›flmas›nda ekstrakardiyak Tl-201 tutulumu
Do¤angün Yüksel, Olga Yaylal›, Turgut Serdafl, F Suna K›raç, Mustafa K›l›ç*
Departments of Nuclear Medicine and Cardiology*, Medical School, Pamukkale University,  Denizli, Turkey
Introduction
An increased non-cardiac uptake of Thallium-201 (Tl-201)
and Tc-99m sestamibi (MIBI) may be seen on the cine view of
myocardial perfusion single photon emission computed tomog-
raphy (SPECT). This unusual radiopharmaceutical accumulation
may be resulted from malignant lesion or it may be a normal va-
riation (1-3). In this case report, we presented the patient with
the high extracardiac Tl-201 accumulation in the right paraster-
nal region. 
Case Report
A 70-year-old man with angina pectoris was admitted to
the Department of Nuclear Medicine for the evaluation of isc-
hemic heart disease. He has suffered from substernal chest
pain, fatigue, dyspnea, cough with sputum for four months and
has been smoking the two packets of cigarettes per day for
forty years. Pharmacological stress-redistribution Tl-201 myo-
cardial perfusion SPECT study was performed following 3 mCi
Tl-201 intravenously injection. An intense Tl-201 uptake was
observed on the lower region of right lung (Fig. 1) during the
evaluation of stress and redistribution SPECT raw data. There
were three focal opacifications in the inferior right lung on the
patient’s chest X-ray. After that, patient underwent thorax
computerized tomography and the lesions with the probability
of malignancy in the superior and middle segments of the right
lung were detected (Fig. 2). The histopathological diagnosis
was an adenocarcinoma. Despite therapy, the patient died two
months later.
Address for Correspondence: Do¤angün Yüksel, MD, Pamukkale Üniversitesi, T›p Fakültesi, Nükleer T›p Anabilim Dal›, Doktorlar Cad. No: 42, 20100 Denizli
Tel-Faks : 0 258 265 17 92, E-Posta: dodergun@hotmail.com
Case Report   Olgu Sunumu
Figure 1. An increased extracardiac uptake pattern (black arrows) views in the right parasternal region of raw projection images with Tl-
201 SPECT myocardial perfusion imaging (A) and anterior static image (B)
A B
Discussion
During the assessment of myocardial perfusion SPECT stu-
dies, the incidence of radiopharmaceutical uptake in extracar-
diac regions is about 2.8 % and the probability of malignancy of
these lesions is 8-10 %. The non-cardiac accumulations of both
Tl-201 and Tc-99m MIBI are most frequently related with the
lung and breast malignancies. Therefore, the raw data have to
be carefully interpreted during evaluation of myocardial perfu-
sion study. If increased radiopharmaceutical accumulations in
the extracardiac areas are observed, they must be reported to
provide the early diagnosis and treatment of malignant lesions
(1-3).
References
1. Williams KA, Hill KA, Sheridan CM. Noncardiac findings on dual-
isotope myocardial perfusion SPECT. J Nucl Cardiol 2003; 10: 395-
402.
2. Kim CK, Jung E, Yun M, et al. A normal variant on Tl-201 and Tc-
99m MIBI whole-body imaging: the superior right atrial wall (auric-
le) and superoanterior right ventricular wall are often seen as
mediastinal lesions. Clin Nucl Med 2001; 26: 412-8.
3. Yamamoto Y, Nishiyama Y, Satoh K, et al. Comparative evaluation
of Tc-99m MIBI and Tl-201 chloride SPECT in non-small-cell lung
cancer mediastinal lymph node metastases. Clin Nucl Med 2000;
25:29-32.
Anadolu Kardiyol Derg
2005;5: 140-1
Yüksel et al.
Non-cardiac Tl-201 uptake on myocardial perfusion 
141
Figure 3. Thorax computerized tomography image shows a malig-
nant lesion with peripheral infiltratiton in the right lung.


Non-cardiac TI-201 uptake on myocardial perfusion SPECT study

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Non-cardiac TI-201 uptake on myocardial perfusion SPECT study

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