OBJECTIVE: To determine the prevalence of sexual function alterations in Mexican subjects with diabetes mellitus (DM) attended in a highly specialized medical unit. MATERIAL AND METHODS: Sociodemographic variables were evaluated, and the DM, male and female sexual function with an ad hoc questionnaire and Female Sexual Function Index or International Index of Erectile Function. Data were processed using the SPSS statistical analysis program version 19. RESULTS: 212 subjects were selected, 120 women and 92 men. The global prevalence of sexual function alterations was 81.1%. In women it was 83.3% and 78.3% in men, with 73.7% and 63.1%, respectively, in those under 40 years of age. The highest prevalence occurred among women aged 50-59 years and men between 60-69 (+/- 95%), married (> 80%), pensioners and women of the household (+/- 90%), with primary educational level (100%), men with type 1 DM or women with type 2 DM (> 85%), and with 21 years or more of DM diagnosis (90-100%). CONCLUSION: The prevalence of sexual function alterations in Mexican subjects with DM is higher than worldwide reported; women have higher prevalence of sexual function alterations than men
