The research aimed to evaluate the geoepidemiological profile of leprosy and its spatially uneven production in the state of Rondonia in the period from 2011 to 2014, from the perspective of medical geography, identifying and performing mapping of critical areas of the spatial production of leprosy. The study it is quantitative, descriptive and retrospective research. Information System Diseases and Reportable - the database SINAN (Sistema de Informação de Agravos e Notificáveis) was used. For the clothing of thematic maps was used ArcGIS program. The research universe was created by the registration of all new cases of leprosy reported in the period from 2011 to 2014, living in Rondonia. The State of Rondonia had 2,972 (two thousand nine hundred seventy-two) new cases of leprosy in the period studied, respectively 827 new cases in 2011, 779 in 2012, 2013 686 and 2014 680, which corresponds to 5.24 detection rate in 2011 4.93 2012 3.96 3.88 2013 and 2014 and are classified as hyperendemic area with detection rate/average incidence of 4.50 per 10,000 inhabitants. Leprosy is present in virtually 100% of the municipalities of Rondonia