Heise, Rebecca L

Ratti, J Alex

Reynolds, Angela

English

VCU Scholars Compass

Virginia Commonwealth UniversityVCU Scholars CompassBiology and Medicine Through MathematicsConference 2018May 31st, 11:30 AM - 12:00 PMInvestigating Smoke Exposure and ChronicObstructive Pulmonary Disease (COPD) with aCalibrated Agent Based Model (ABM) of In VitroFibroblast Wound Healing.J Alex RattiVirginia Commonwealth University, rattija@vcu.eduAngela ReynoldsVirginia Commonwealth UniversityRebecca L. HeiseVirginia Commonwealth UniversityFollow this and additional works at: https://scholarscompass.vcu.edu/bammPart of the Disease Modeling Commons, Disorders of Environmental Origin Commons, LifeSciences Commons, Other Biomedical Engineering and Bioengineering Commons, PhysicalSciences and Mathematics Commons, Respiratory Tract Diseases Commons, and the Systems andIntegrative Engineering CommonsThis Event is brought to you for free and open access by the Dept. of Mathematics and Applied Mathematics at VCU Scholars Compass. It has beenaccepted for inclusion in Biology and Medicine Through Mathematics Conference by an authorized administrator of VCU Scholars Compass. Formore information, please contact libcompass@vcu.edu.https://scholarscompass.vcu.edu/bamm/2018/thursday/14Investigating Smoke Exposure and Chronic Obstructive Pulmonary Disease (COPD) with a Calibrated Agent Based Model (ABM) of In Vitro Fibroblast Wound Healing.  James A. Ratti1, Angela M. Reynolds, Ph.D.2,3, Rebecca L. Heise, Ph.D.1,3 1Pulmonary Mechanobiology Lab, Dept. of Biomedical Engineering, 2Dept. of Mathematics & Applied Mathematics, Virginia Commonwealth University (VCU), 3The VCU Johnson Center, VCU Medical Center, Richmond VA  COPD is characterized by tissue inflammation and impaired remodeling that suggests fibroblast maintenance of structural homeostasis is dysregulated. Thus, we developed an ABM of lung fibroblasts healing a wound using NetLogo to evaluate differences among cells from COPD patients. This ABM consists of a set of rules governing the healing response, accounting for cell migration, proliferation, death, activation and senescence rates; along with the effects of heterogeneous activation, phenotypic changes, serum deprivation and exposure to cigarette smoke condensate or bFGF. Simulations were performed to calibrate parameter sets for each cell type using in vitro data of scratch-induced migration, viability, and expression of senescence-associated beta-galactosidase or alpha-smooth muscle actin. This model represents the prototype of a computational tool designed to explore the role of lung fibroblast functions in the pathogenesis of COPD and evaluate potential therapeutic strategies. 

Investigating Smoke Exposure and Chronic Obstructive Pulmonary Disease (COPD) with a Calibrated Agent Based Model (ABM) of In Vitro Fibroblast Wound Healing.

https://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=1258&amp;context=bamm

Investigating Smoke Exposure and Chronic Obstructive Pulmonary Disease (COPD) with a Calibrated Agent Based Model (ABM) of In Vitro Fibroblast Wound Healing.

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