Sestre Milosrdnice University hospital and Institute of Clinical Medical Research
Abstract
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease. It is suggested that angiogenin (ANG) may play a role in the pathomechanisms of this disease. The aim of the study was to measure cerebrospinal fluid (CSF) ANG levels in patients with ALS. Twenty ALS patients and 15 control subjects were included in the study. CSF ANG levels were measured by ELISA. Study results showed that CSF ANG level did not differ between ALS patients and control group (p>0.05). There was no significant correlation between CSF ANG level and clinical state of ALS patients either (p>0.05). The present study conducted on CSF of patients with ALS did not confirm previous observation on the possible role of ANG in neurodegeneration in this disease.Amiotrofična lateralna skleroza (ALS) je neurodegenerativna bolest. Pretpostavlja se da bi angiogenin (ANG) mogao imati ulogu u patomehanizmu ove bolesti. Cilj ove studije bio je izmjeriti razine ANG u likvoru bolesnika s ALS. U studiju je bilo uključeno 20 bolesnika s ALS i 15 kontrolnih osoba. Razine ANG u likvoru mjerene su metodom ELISA. Ispitivanje je pokazalo kako nema razlike u likvorskoj razini ANG između bolesnika s ALS i kontrolne skupine (p>0,05). Isto tako nije bilo značajne korelacije između razine ANG u likvoru i kliničkog stanja bolesnika s ALS (p>0,05). U zaključku, ova studija provedena na likvoru bolesnika s ALS nije potvrdila prijašnja zapažanja prema kojim bi ANG mogao biti upleten u neurodegenerativne procese ove bolesti
