Combined Use of Vancomycin and Meropenem in Patient with Acute Intermittent Porphyria: A Case Report

Abstract

Acute intermittent porphyria (AIP) is an autosomal dominant disorder that leads to abdominal pain with unknown etiology, nausea, acute peripheric and/or central nervous system disfunctions, hiponatremia and with existence of phorphobilinogen in urine during acute attacks. Young females are more often symptomatic than males. Porphyria attacks arise from outer induction of heme synthesis in liver such as drugs that induces mithocondrial cytochrom P-450. A few antibiotics are considered as safe in patients with porphyria. A quite less previous case were reported in literature about uses of vancomycin and meropenem seperately. However vancomycin plus meropenem combination therapy was not reported in any case with porphyria. In this paper we reported a patient with AIP treated with combined vancomycin plus meropenem therapy because of lifethreatening nosocomial sepsis and had not any side effect