To the question of biosafe level of exposure of relatively-pathogenic yeast-like mycotic substances

Abstract

Performed studies showed an actual dosed aerogenic load of microorganisms-producers of a fodder-protein on the organisms of workers of two enterprises of microbiological industry. A quantitative value of air pollution levels of a working zone allowed to reveal the dependence of a production-induced morbidity, mico-carrying and a specific resistance of organism to a dosed load of microorganism-producers. The following levels of risk were identified: minimum when the actual dosed load does doesn't exceed the limits of the normative; increased when the actual dosed load exceeds the normative up to 6,5 times; high when the ratio of the excess is more than 6,5 times. The frequency of detection of criteria significant indices of prenosological diagnostics (combination of mico-carrying with positive results of allergotests) in the zone of minimal risk gradually grows and. is insignificant at the same time. While the dosed load is growing the number of working with a combination of these symptoms increases too. In the zone of high risk there is a sharp rise of frequency of detection of indices, that are the criteria of prenosological diagnostics of professional risk. The proposed criteria of risk of the development of vocational and production-induced pathology will allow occupational pathologists and. craft physicians to link the resulting violations in the health status of employees with an action of professional microbial factor even in the absence of the maximum allowable concentration of microorganisms-producers in the air of industrial premises. A safe level of exposure to microorganism-producers of a fodder protein cannon be recommended on this stage of the study, because even a minimal dosed load would lead to forming myco-carrying, specific alterations of an immune system and. higher levels of production-induced morbidity. While analyzing the results of the conducted. work we can conclude that the concept of limen concentration at the regulation of maximum allowable concentration for relatively-pathogenic microorganisms-producers needs to be clarified and. its possible adjustment and. dosed load of microorganisms-producers of the positions dose-spectacular dependencies requires more cautious approach to the evaluation for the enterprises of biotechnological synthesis