取得学位：博士(理学)，学位授与番号：博甲第1047号，学位授与年月日：平成20年9月26

Acep Purqon

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取得学位：博士(理学)，学位授与番号：博甲第1047号，学位授与年月日：平成20年9月26日othe

Acep, Purqon

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Kanazawa University Repository for Academic Resources

氏名学位の種類学位記番号学位授与の日付学位授与の要件学位授与の題目ACEPPURQON博士（理学）博甲第1047号平成２０年９月２６日課程博士(学位規則第４条第１項）ＳＨＡＰＥＦＬＵＣＴＵＡＴＩＯＮＭＯＤＥＳＡＮＤＳＹＮＣＨＲＯＮｗｚＡＴＩＯＮＥＡＴＴＥＲＮＳＩＮＳＥＬＦ－ＡＳＳＥＭＢＩｊＹＡＧＧＲＥＧＡＴＥＢＩＯＮＡＮＯＣＬＵＳＴＥＲＳ．（生体ナノクラスタ自己集積集合体における構造揺らぎモードと同期パターン）長尾秀実（理工研究域・教授）西川清（理工研究域・教授)，斎藤峯雄（理工研究域・教授)，高須昌子（理工研究域・准教授)，長山雅晴（理工研究域・准教授）論文審査委員（主査）論文審査委員（副査）ＡＢＳＴＲＡＣＴIcvaluateshapefluctuationsinselfassemblyaggregatcbionanoclustersbyintroducingconceptsofapcrturM,symmetry-aisotropy-Landcompactncss-CEachconcepthasphysicalmeaningandconcernwithsuchkinddegreeoftailfluctuation,shapefluctuation,parallelism,andclusterstability，respectively、Althougllthcdynamicsofthoseparametcrsexhibitrandomprocesses，theyshowcoIrclationwitheachotheLImainlydiscussthecorrelationorcouplingofIとＣａｎｄＩＬＳ・ThecouplingoffCcanexplainpossiblestableshapeofbioaggcgates,while,thecouplingofZLScanclassifythemintofOurclustermodes､Inaddition,thecouplingofIとSshowsfilzzyclusterregionsassmoothtransitionsofthemodes,Atdifferentconditionsuchassaltywateranddifferenttcmperature，theparametersconsistentlyshowthcshapcflu1ctuationmodes・Interestingly）theregionsofshapefluctuationsmthesaltywatershowslightlydifferentandapparentlyfO11owanuctuationline・Furthennore,thewiderfluctuationlincandjunlpmotionsparticipateinoccumngnon-GaussianphenomenafOrthcpurewateエFinally，wediscussmutualclustcrdynamics・Unlikeindividualclustersthatlnai､lyshowrandomnuctuation,mutualclustersshowcertainpattemsindelayedtimcanalysissuchasmutualfluctuationsperiodicallyoccurfOrsamenumberoflipids・Itindicatesthatancxistenccofsynchronizationpatternsoccurs．ＳＵＭＭＡＲＹInthisthesis,Imainlydiscussfiveissuesonselfassemblyaggregatebionanoclusters､ThefiveissueareasfD11ows:developingmethodtomeasuredegreeoffluctuations,ｃlassifyingthenuctuationpattems，identifyingsmoothtransitionsoftheshapes,identifyingsolventeffects,andinvestigatingsinlultaneouslyfluctuationonmutualbionanoclusters・WeperfOnnseveralmoleculardynalnicssimulationsfOrPOPCandPOPE1ipidsatvariousconditions、hfirstissue,weproposeatechniquctoanalyzethedynamicsbasedontheconceptSofape血reH，symmetry-Sisotropy-Landcompactness-C・EachparameterhasphysicalmeaningWefOundsomeinterestingphenomenainthedynamics,density，andcorrelationamongthoseparameters、A1thoughthedyllamicsofthoseparametersexhibitralldomprocesses，theyhavecoIrelationwitheacllotherbThisanalysiscanalsoexplainthepossibleshapesinbiologicalsystemssuchasmicelle,vesicleormembrane・Insecondissue,weclassifytheirregUlarshapesbyusmgthecouplingofSLI(symmetryandisotropy).WefindfOurshapcnuctuationmodes:spherc-1ike,rod-1ikc,conc-1ike,andmonolayer-like・hthirdissue，weinvestigatesmoothtransitionsoftheshapesleadingtofilzzyclustermodes・TorevealthetransitionS，ｗeperfOnnfUzzyc-meansclustering・Wefindnotonlybetterclassificatiｏｎｏｆｍｉｃellarclustermodesandtheirtransitionregionsbutalsocandetenninemoreproper－１４－positiontodefineeacllmodeonfuzzyregionInfOrthissue，weinvestigatesolventcffCctsoneachparaInetenFronlthercsults，addingsaltandincreasingtemperaturegenerallychangeeacllparameterandcontributeonshapefluctuations，hterestingly，ｔｈｅｒｅgionsofshapefluctuationsintllesaltywatershowsligj1tlydifferentthaninthepurewaterbItapparentlyshowsthattheyfO11owafluctuationline・Thenuctuationlinelikelycontributesinoccurringnon-GaussiandistributionsfOrthepurewaterlnfifthissue，thejumpmotionslikelycontributcontheexistenccoftransitionsinthenon-Gaussiandistributions、Additionallylevennulnbersoflipidsshowmoresynlmetricthantheoddnulnbersoflipidsandthesymmctrydistributionsareshiftathigllertemperature、FiDnlpowerspectradcnsityanalysis，eachindividualclustershowsnearlyrandomfluctuation・Besideofindividualclusters，wealsoinvestigatemutualclusters・Surprisingly，althoughindividualclustersfluctuaterandolnlyうmutualclustersshowcertaindirectioncorrelations・Moreover）theyshowcertainpatternsindelayedtimeanalysissuchasmutualfluctuationsperiodicallyoccurfOrｓａｍｅｎｕｍｂｅｒｏｆｌｉｐｉｄｓ・Itindicatcsthatanexistenceofsynchronizationpatternsoccursinshapenuctuationsofthebionanoclusters．学位論文審査結果の要旨…護該裳位論文1皇關と正９－畳議糞員迩個量り1二検討上面援調蕊遂ﾂﾞ:、迄籏.…論糞1ii1餐遂護趨Ｉ三検討L:た．__量Ｑ後悪成-2ＷL窪旦且全旦ｊ皇征ね虹進且頭発表璽後』異議蕊委員会遂關童勤。協議Ｑ錆暴黙]E幻よ-ｺj皇劉旗寧L葱迄｡－－－………－－……………………＿…＿……＿…杢論文j菫念壬j1i2L;ｵﾕﾐ義弘夏晶叱冤Ｚ目_悪に聖-,91数ＱｊｊＬｚ臆質二重膜徽fji1jM1l質ziﾐ良なゑ良種止抜之乏疑麦ＺｎｆＭ土塁ｊｚｆ孟1皇關式ゑ班窓童衝且工叫;;１．－息延堕奴擬成分轟蕊公設数蜜度Ｉ皇よｎ重灘数_:毫興雄よ鼠抜壼:_捧雄な雲煙雄途i三なゑ息怠塗ﾐ裳鹸基惣息晶罎陛孟莫具髭1塁典、藤抗亘ii進めゑれ百三ikAlゑ゛－１_旦搬成分王患二重○三.迄止賦之乏丞蕊４Ｍﾑﾊﾟf±臭以'lZZi塗耀抜まゑ違い』皇藪と虹溌抜友撞迄撮案必…二迄と描造璽広蕊圦_:篁就議践_二霧友憧雪:藝太重重Ｉ三霞丈量晴間発巌童溌撒上i二ＭL；蕊も三迄瘡』墜批玄.重ZL笈五1菫ニオェ丘璽猿蜂燃－１重｝重量望還金窪議造揺息籔遂Ｌｊｎ２魚息と塗良Ｗ三上進鱒~急の櫨造籍阜董』蝋度蕊高二一蓮鐘上本登基一な－，鐸ＭＩＬ衣望遂貧歎本溶撞吏逼迫本章≦_窪鍾息怠迄鼠町篁上蒼鰍)量｡~二種止闇幻鑓麗遂鱸抜と…念孟重Ｉ園数種ゑゑ姦乏丞袰聞冒ご｝寡園識鞄鰯熱：鑓關迄鰍>蛙園調塗丞宣亘息と童量』.〕童.し台塞｡‐必上璽駈髭｝鋤_墓贈質二重膜構成物質員童よ抜之乏丞蔓、堂エゴニミユ典泉1三鐘lL》二直丞溌液幻震襄撲産示唆“…会後Ｑ襄験班究｝皇姦≦_典議長遂坦迄息戴ｊＭ２重塵息｡~製上}皇よp_』_忌璽論文1寡壌土…<蕊裳Ｍ三億立査:Ｍ)と髪！旗L急進.－－－…－１５－

Shape fluctuation modes and synchronization patterns in self-assembly aggregate bionanoclusters

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生体ナノクラスタ自己集積集合体における構造揺らぎモードと同期パターン

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