Regarding to monitor of demersal resources in the Persian Gulf and Oman Sea, and also biomass and CPUA estimation of them, a series of research cruises (5 cruises per year) were carried out by R/V Ferdows-1covering the area from 49 00 E in the west (Khoozestan provice) to 61 25 E in the east (Gwater) in a 5 years program form 2004 up to 2008 (no cruise in 2006). The study area was stratified into 17 strata (A to Q) of which 10 starta (A to J) were in the Persian Gulf and 7 strata (K to Q) were in the Oman Sea, covering the depths of 10-50m in the Persian Gulf and 10-100m in the Oman Sea. A total of 316 stations were randomly selected. The biomass and CPUA were estimated by Swept Area method. The comparison between two regions indicated that the percentage of density of demersal fishes in the Persian Gulf during years 2004, 2005, 2007 and 2008 were 3.3, 3.9, 2.3 and 2.4 times more than the Oman Sea and totally 70-80% of total biomass was calculated for the Persian Gulf. Also a comparison among 17 starta, the highest biomass was found for starta C & D in the Bushehr province waters. The amount of CPUA for both regions of the Persian Gulf and Oman Sea was compared and it was concluded that in years 2004 and 2005, the mean CPUA in the Persian Gulf was partially higher than the Oman Sea with 1.06 & 1.20 times more; and on the contrary for the next two years this value was higher in the Oman Sea with 1.3 times more. The highest CPUA of demersal resources for the Oman Sea belonged to the strata K & O for years 2004, 2007 and 2008 and for year 2005 was for L and strata. It can be concluded that the north-west of Oman Sea has the best condition of biomass of commercial and non-commercial species and the O stratum will be in the second ranking. With review the mean CPUA in different depth-layers for years 2004, 2005, 2007 and 2008, it was concluded that with increasing the depth, the mean CPUA is decreased in which the CPUA values in depth-layer 10-20m for these years were 8.3, 3.0, 2.1 & 1.6 times more than depth-layer 50-100m. The comparison of mean CPUA for 10 strata of the Persian Gulf showed that in years 2004 and 2005, the mean CPUA of demersal fishes in the Hormuzgan province waters was higher than in Bushehr province waters (1.2 times more). In total, the highest maen CPUA belonged to F (Naiband to Mogham) and G (Mogham to Farour) in Hormuzgan waters. On the contrary, in years 2007 and 2008 this value in Bushehr waters was 1.3 times higher than western part of Hormuzgan waters with the highest value in D stratum(Boordekhoon to Dayyer). Also the comparison of mean CPUA for different depth-layers, it was found that the mean CPUA has ascending trend with increasing the depth, with the highest value in depth-laer of 30-50m in which contains the 55-68% of total biomass. The lowest biomass is found in depth-layers of 10-30m. Totally, the minimum CPUA and biomass for both commercial and non-commercial species belonged to a stratum located in Khouzestan province waters and it was shown the over-exploitation of resources in this area. The comparison between commercial and non-commercial groups in both ecosystems , it was concluded that the density of commercial species was higher than non-commercial ones , and in all years the Persian Gulf indicated higher values than the Oman Sea