An extended pulse wave propagation model to predict (patho-)physiological coronary pressure and flow patterns

Abstract

A patient-specific model describing the primary relations between the cardiac muscle contraction and coronary circulation might be useful for interpreting coronary hemodynamics and deciding on medical treatment in case multiple types of coronary circulatory disease are present. For this purpose we present the use of a microstructure-based heart contraction model and a micro-structure based fiber reinforced arterial wall model as the basis of a 1D wave propagation model to describe coronary pressure and flow waves. We conclude that this extended pulse wave propagation model adequately can predict coronary hemodynamics in both normal and diseased state based on patient-specific clinical data

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