Altan-Bonnet

Banavali

Bruner

C. Gu

C. He

C. Yi

Chen

Dallmann

Edman

G. Zheng

Giudice

Gu  ron

Klimasauskas

L. Yang

Mills

Obmolova

Parker

Priyakumar

Roberts

Slupphaug

Spies

Vallur

V  rnai

Watkins

X. S. Zhao

Y. Q. Gao

Y. Yin

Yang

Zhuang

Significance
          Spontaneous flipping of a single DNA base to an extrahelical position is a fundamental issue in DNA biophysics. The dynamics of such spontaneous flipping of a lesion or mismatched base is an important biophysical feature of DNA to discriminate damaged base from normal Watson–Crick paired ones. It is therefore closely related to repair enzymes' function to recognize base lesions, a mechanism on which almost all organisms rely to maintain their genome integrity. However, it has remained challenging to obtain reliable thermodynamics and kinetics data on this process. By developing experimental and theoretical techniques, we determined the free energy and rates of DNA spontaneous base flipping, providing further insights into its molecular mechanism.</jats:p

Yandong Yin

Lijiang Yang

Guanqun Zheng

Chan Gu

Chengqi Yi

Chuan He

Yi Qin Gao

Xin Sheng Zhao

Crossref

Proceedings of the National Academy of Sciences

Dynamics of spontaneous flipping of a mismatched base in DNA duplex

Dynamics of spontaneous flipping of a mismatched base in DNA duplex

Abstract

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