Epiregulin (EPR) and amphiregulin (AR) inhibited cell death in Neuro2a cells.

Abstract

<p>The cells were pretreated with EPR (0.01, 0.03, 0.1, and 1 nM) and AR (0.001, 0.01, 0.03, 0.1, and 1 nM) for 1 h and subsequently treated according to the indicated conditions. (A) EPR reduced the release of lactate dehydrogenase (LDH) at 48 h after Tm (1 μg/mL) treatment. (B) AR reduced the release of LDH at 48 h after Tm (1 μg/mL) treatment. The LDH released into the medium was expressed as a percentage of the control value. The data represent the average of 4 independent experiments for each sample. *p < 0.05.</p

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