Coito, A.

De Meester, Ingrid

Graser, E.

Korom, S.

Kupiec-Weglinski, J.W.

Scharpe, Simon

Schwemmle, K.

Volk, H.D.

Abstract: Background: The intrinsic catalytic dipeptidyl peptidase IV activity of the T cell activation Ag CD26 is crucial for its costimulatory efficacy. Methods:In this study, we investigated the immunomodulatory effect of CD26/DPP IV,by targeting its catalytic moiety. Results: Treated recipients showed a significant and rapid decrease in TCR, CD3 and CD45 cellular expression kinetics on PBL and a reduction in IL-2 and IFN-gamma intragraft mRNA expression. Enzymatic inhibition during sensitization abrogated accelerated rejection in > 50% of treated recipients. Conclusion: These findings further support the hypothesis that DPP IV/CD26 is associated with allo-Ag mediated immune responses, indicating a graded but central involvement in pathways of cellular and humoral immunity

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Immunomodulatory influence of CD26 dipeptidyl-peptidase IV during acute and accelerated rejection

Immunomodulatory influence of CD26 dipeptidyl-peptidase IV during acute and accelerated rejection

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Institutional Repository Universiteit Antwerpen