<p>Mouse blood plasma samples were processed by Western blot analysis using antibodies to LB509 (<b>A</b>) and Syn-1 (<b>B</b>). Both monomer and dimer α-synucleins were found in mouse plasma. Sample images are shown for each Western blot. (<b>C, D</b>) Quantitative α-synuclein plasma levels are shown for each group after being normalized to mouse serum albumin. With both LB509 (<b>A</b>) and Syn-1 (<b>B</b>) antibodies, there were significant increases in α-synuclein monomer, dimer and total (monomer plus dimer) fractions in Exercise versus Non-Exercise mouse plasma (n = 7, t-test, *<i>p</i><0.05).</p