International Society for Magnetic Resonance in Medicine
Doi
Abstract
Synopsis
Liver transplantation is the only cure for end-stage liver disease. Unfortunately, 20% of patients die waiting for a donor. New techniques for
preserving transplant livers, such as normothermic machine perfusion (NMP), provide an opportunity to utilise ‘marginal’ (currently discarded)
donated livers if their viability can be assessed accurately. We present initial results from a CE-marked NMP system that we adapted for use in
an MRI scanner. We demonstrate the power of NMP-MRI to assess structure and metabolism in a freshly donated pig liver, dynamically over a
10-hour period. Our protocol includes H imaging, P spectroscopy, and hyperpolarised C spectroscopy.This work was funded by a Sir Henry Dale Fellowship from the Wellcome Trust and the Royal Society (Grant No. 098436/Z/12/Z) and by the National
Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC)