The aim of this article is to describe the factors that facilitate upgrading process of knowledge-intensive business services (KIBS) clusters in global value chains. The observed phenomenon which can be described as an increase in value added produced by KIBS leads to a similar increase at the clusters’ level, and consequently to an increase in the position of these clusters in global value chains. This topic constitutes a new research area. The available definitions of clusters were reviewed. The nature and specificity of knowledge-intensive business services’ clusters were presented. The concepts of upgrading and global value chains were defined and the idea of upgrading of KIBS’ clusters in global value chains were presented. As a result of the literature analysis, endogenous and exogenous factors influencing the upgrading of clusters in global value chains were presented. The article is conceptual and based on scientific literature, the review of which was a research method used