Course of infection caused by TIGR4 and SRL1.

Abstract

<p>C57Bl/6 mice were infected with either TIGR4 (5 x 10⁶ cfu/mouse) or SRL1 (10⁶ cfu/mouse) by intranasal inoculation and culled at pre-determined intervals. Bacteria were enumerated in BALF (A), pleural aspirate (B) and blood (C). Concentration of IL-17A in BALF (D) and MPO in lung (E) were determined. (F) H&E tissue sections of mice infected for 48 hours at original magnification of x4. G. Immunohistochemistry using the neutrophil marker Ly-6G at an original magnification of x40. Points are means from three animals; bars show SEM. Representative of two independent experiments.</p