Model predictions agree with neuroblast migration data.
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Abstract
<p>(A) Number of <i>mig-1</i> mRNA molecules per cell as a function of time <i>t</i>, obtained by single-molecule fluorescent in situ hybridization, from [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1006201#pcbi.1006201.ref005" target="_blank">5</a>]. Magenta shows approximate range of times when cell migration terminates. Black lines show mean (dashed) and standard deviation <i>σ</i><sub><i>d</i></sub> of cell division times (black points). (B) Timing variance vs. linearity of <i>x</i>(<i>t</i>), both for experimental data in A (blue circle) and our model (curves, Eqs <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1006201#pcbi.1006201.e049" target="_blank">16</a> and <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1006201#pcbi.1006201.e050" target="_blank">17</a>). Data analyzed using ranges of threshold 10 ≤ <i>x</i><sub>*</sub> ≤ 25 and bin size 3 ≤ Δ<i>x</i> ≤ 12; error bars show standard deviations of these results. We see that for sufficiently large cost 〈<i>a</i>〉/<i>x</i><sub>*</sub> or 〈<i>r</i>〉/<i>x</i><sub>*</sub>, model predictions agree with experimental data point.</p