Rhodium(I)-Catalyzed C8-Alkylation of 1‑Naphthylamide Derivatives with Alkenes through a Bidentate Picolinamide Chelation System


The rhodium­(I)-catalyzed C–H alkylation of 1-naphthylamide derivatives with alkenes at the C8-position using a picolinamide directing group is reported. Various alkenes including styrene derivatives, α,β-unsaturated carbonyl compounds, and even unactivated alkene could also be used as coupling partners. The reaction mechanism was investigated in kinetic studies, deuterium labeling studies, and control experiments. The reaction appears to proceed through a rhodium carbene intermediate, which is generated from an alkene

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