Gompertz AD onset risk function for the general population (“baseline”), the subject’s estimated APOE status (“genetic risk”), and risk factoring in known risk factors (“factored risk”).

Abstract

<p>Notice the risk increases steadily until approximately age 80, at which point the risk grows at a slower rate. This is because there is a probability that this individual will never have AD. The baseline risk is calculated by applying the model to the “average” person, that has APOE4 genotype probability status equal to that of the population.</p

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