Dynamics of subcellular localization of Rbfox1 during early postnatal development of the retina.
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Abstract
<p>A. At P0, along with cells with cytoplasmic Rbfox1 expression, there are cells in the GCL with pronounced nuclear staining (pointed by arrows). Most of Rbfox1 and Rbpms expression is colocalized indicating that these cells are RGCs. B and C. At P5, Rbfox1 expression switches to be predominantly nuclear especially in RGCs and dACs. More cells with nuclear expression of Rbfox1 also appear in the INL. Arrows point at several cells in the GCL and INL with Rbfox1 nuclear staining. D. A significant overlap exists between Rbfox1 and Rbfox2 expression at P5, though in both, the GCL and INL, there are cells with specific expression of one or the other paralog. Rbfox1 staining in the IPL (B, C and D) is non-specific since it was also observed in a control experiment with only secondary antibodies. Blue and white arrows point at several Rbfox1-positive/Rbfox2-negative and Rbfox2-positive/Rbfox1-negative cells, respectively.</p