KN1 mice exhibit a reduced energy cost of muscle contraction.

Abstract

<p>The energetic cost (maximal ATPase activity divided by force output) of muscle contraction was calculated at different muscle fractional activation states. Muscle activation is normalized muscle force output over the range of Ca²⁺ concentrations in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0200834#pone.0200834.g003" target="_blank">Fig 3</a>. Demembranated papillary muscles from KN1 mice exhibited a lower energy cost of contraction than wild type controls. KN2 papillary muscles exhibited a similar energy cost of contraction to wild type controls. n = 10–12 mice (2–4 fibers per mouse). Two factor ANOVA, ***** p < 0.001 WT versus KN1, #### p < 0.001 KN1 versus KN2.</p