nNOS inhibition has no impact on force responses to Ca<sup>2+</sup> transients in intact papillary muscles.

Abstract

<p>The impact of nNOS splice variant deficiency on the normalized force (fraction of maximum) response to Ca<sup>2+</sup> transients (shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0200834#pone.0200834.g005" target="_blank">Fig 5</a>) was determined in intact papillary muscles at different stimulation frequencies. Normalized force output from intact papillary muscles from KN1 and KN2 mice was indistinguishable from wild type controls, and from each other, at stimulation frequencies between 1 and 3 Hz. The bottom right panel shows a high magnification image of normalized force output between 250–300 ms (gray box in bottom left panel-3 Hz stimulation) in intact papillary muscles from wild type, KN1 and KN2 mice to highlight extensive data overlap. n = 4–6 mice per group.</p

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