Chiral Metal–Organic Framework Decorated with TEMPO Radicals for Sequential Oxidation/Asymmetric Cyanation Catalysis

Abstract

A chiral porous metal–organic framework (MOF) decorated with radicals has been successfully constructed by cocrystallizing achiral (2,2,6,6-tetramethylpiperidin-1-yl)­oxyl (TEMPO)-substituted tricarboxylate and enantiopure VO­(salen)-derived dipyridine ligands. The chiral MOF can function as an efficient heterogeneous catalyst for the sequential alcohol oxidation/asymmetric cyanation of aldehyde reactions with enhanced activity and enantioselectivity compared to the homogeneous counterpart