<p>Two flavone di-<i>C</i>-glycosides, a pair of isomers, were isolated from <i>Scutellaria baicalensis</i>. The structures of compounds <b>1</b> and <b>2</b> were elucidated by means of physical data, including 1D and 2D NMR and HR-ESI-MS. Supporting theoretical calculations of the compound conformational landscape has also been conducted for geometry optimization. This is the first report of the natural occurrence of <i>β</i>-furanoarabinoside. In addition, the effects of compounds <b>1</b> and <b>2</b> on NO, pro-inflammatory cytokines, PGE2 and COX-2 levels were measured in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. The pair of isomers exhibited significant inhibitory effects on inflammation.</p
