Representative examples of immunohistochemistry staining for the four MMR proteins.
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Abstract
<p>Tumors with MLH1-deficiency (dMLH1) show negative expression in both MLH1 and PMS2 IHC, those with MSH2-deficiency (dMSH2) show negative expression in both MSH2 and MSH6 IHC, with PMS2-deficiency (dPMS2) they show negative expression only in PMS2, and tumors with MSH6-deficiency show negative expression only in MSH6.</p