Additional file 9: of IMP1 regulates UCA1-mediated cell invasion through facilitating UCA1 decay and decreasing the sponge effect of UCA1 for miR-122-5p
Figure S6. A proposed model of IMP1 to regulate the sponge effect of UCA1 for miR-122-5p. (A) UCA1 sponges miR-122-5p, reducing miR-122-5p interaction with target mRNA. (B) Increasing IMP1 expression allows IMP1 to bind to UCA1 and to release miR-122-5p from UCA1. This increases the availability of miR-122-5p to interact with target mRNA. (C) Binding to target mRNA allows miR-122-5p to assert its posttranscriptional function. (D) IMP1 binds to UCA1 and recruits it to the CCR4-NOT1 complex, initiating UCA1 decay process. (TIFF 1116 kb
