<p>Superimposition of canIL-13 and huIL-13 molecules, (3D reconstruction using JMol), <b><i>A.</i></b> Purified canIL-13.E13K and canIL-13.E13K cytotoxin, (10% SDS-PAGE), <b><i>B</i><i> and </i><i>C</i></b>. Activation of TF-1 cells proliferation by cytokines, <b><i>D</i></b>. Cytotoxicity of canIL-13 cytotoxin and its neutralization on BTCOE 4795 human GBM cells, <b><i>E</i></b>. P<0.015 and <0.007 for differences between the cytokines (in <b><i>D</i></b>) and the cytotoxin killing vs. neutralization with canIL-13.E13K alone (in <b><i>E</i></b>) using an unpaired t-test. Cytotoxicity of canIL-13.E13K cytotoxin on canine GBM G06-A cells, <b><i>F</i></b>. Cytotoxicity of canIL-13.E13K cytotoxin on human GBM established (U-251 MG), <b><i>G</i></b>, and low passage human GBM cells (BTCOE 4795), <b><i>H</i></b>. CTL – control. Vertical bars represent SEM and if not seen, they are smaller than the points.</p
