General function of Ct in apoptosis repression and induction of differentiation.

Abstract

<p>(A, E, I) Scanning electron micrographs of individual ommatidia of adult <i>Drosophila</i> fly eyes with indicated genotypes are shown. The closed, red arrowheads in (A) mark interommatidial bristles, the open, red arrowheads in (E) mark the absence of these structures. The closed, light red arrowheads in (I) indicate the presence of tissue that would normally develop into interommatidial bristles. (B, F, J) Projections of consecutive confocal sections of one ommatidium of 50 h pupal retinas labeled with DE-Cadherin. Interommatidial bristles are marked by red, closed arrowheads in (B). Open arrowheads in (F) mark absence of DE-Cad, light-red arrowheads in (J) mark reduced DE-Cadherin levels in shaft cells of interommatidial bristles. (C, G) Projections of consecutive confocal sections of one ommatidium of 50 h pupal retinas of <i>GMR::lacZ</i> control (C) and <i>GMR::ct<sup>RNAi</sup></i> flies (G). (D, H) Expression of the apoptosis marker Caspase-3 (Casp-3) in 3<sup>rd</sup> instar eye-antennal discs of control <i>Dcr2; ey::lacZ</i> (D) and <i>Dcr2; ey::2xct<sup>RNAi</sup></i> (H) animals. Yellow asterisks in (H) mark Casp-3 positive cells in <i>Dcr2; ey::2xct<sup>RNAi</sup></i> eye imaginal discs. (K) Relative mRNA expression levels of <i>rpr</i>, <i>grim</i>, <i>Wrinkled</i> (<i>W</i>) and <i>sickle</i> (<i>skl</i>) in 3<sup>rd</sup> instar eye-antennal discs of control <i>Dcr2; ey::lacZ</i> and <i>Dcr2; ey::2xct<sup>RNAi</sup></i> animals.</p

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