Immature regions show lower expression of <i>MAPT</i> and exon 10.

Abstract

<p><b><i>A</i>,</b> Regional and temporal variation in <i>MAPT</i> expression, <b><i>B</i>,</b> exon 2 splicing, <b><i>C</i></b>, exon 3 splicing and <b><i>D</i>,</b> exon 10 splicing. *Region with p<0.05 by generalized linear model including age, region, sex and RIN score as covariates, Bonferroni’s correction for multiple comparisons. ⁺Reference region. <i>CGE</i> caudal ganglionic eminence, <i>DIE</i> diencephalon, <i>DTH</i> dorsal thalamus, <i>FC</i> frontal cerebral wall, <i>LGE</i> lateral ganglionic eminence, <i>MGE</i> medial ganglionic eminence, <i>OC</i> occipital cerebral wall, <i>PC</i> parietal cerebral wall, <i>TC</i> temporal cerebral wall, <i>URL</i> upper rhombic lip, <i>VF</i> ventral forebrain, <i>A1C</i> primary auditory cortex, <i>AMY</i> amygdala, <i>CBC</i> cerebellar cortex, <i>DFC</i> dorsolateral prefrontal cortex, <i>HIP</i> hippocampus, <i>ITC</i> inferior temporal cortex, <i>M1C</i> primary motor cortex, <i>MD</i> mediodorsal nucleus of the thalamus, <i>MFC</i> medial prefrontal cortex, <i>OFC</i> orbital prefrontal cortex, <i>S1C</i> primary sensory cortex, <i>STC</i> superior temporal cortex, <i>STR</i> striatum, <i>V1C</i> primary visual cortex, <i>VFC</i> ventrolateral prefrontal cortex, regions are defined in [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0195771#pone.0195771.ref027" target="_blank">27</a>].</p