Effect of vaccination of humans with subunit influenza vaccines on Treg frequency.
- Publication date
- Publisher
Abstract
<p>At day 0, healthy adults were i.m. vaccinated with a non-adjuvanted (Agrippal<sup>®</sup>) or MF59<sup>®</sup>-adjuvanted (Fluad<sup>®</sup>) trivalent influenza subunit vaccine or injected with a placebo. At day 1, 3, 5, 14 and 21 post vaccination changes in Treg frequency were determined. The delta Treg percentage per time point was determined per donor (= % Treg day<sub>x</sub>—% Treg day<sub>0</sub>). Mean (± SEM) delta percentage of the frequency of rTreg (left) and aTreg (right) in the blood at the different time points after vaccination with Agrippal<sup>®</sup> (n = 12), Fluad<sup>®</sup> (n = 8, day 14 n = 2) or placebo (n = 6). Means were statistically compared with a Kruskal-Wallis test.</p
