Human CXCR4 knock-in design and confirmation of human CXCR4 expression in peripheral blood cells of heterozygous (HuCXCR4KI/WT) and homozygous (HuCXCR4KI) mice.

Abstract

<p><b>A</b>, Schematic of genetic targeting strategy for knock-in of full length human CXCR4 coding region. <b>B</b>, Flow cytometric analysis of peripheral blood leukocytes from littermate mice with antibodies specific for human CXCR4.</p