Additional file 4: of Methotrexate upregulates circadian transcriptional factors PAR bZIP to induce apoptosis on rheumatoid arthritis synovial fibroblasts
Cell viability of MTX-treated fibroblasts. Cell viability of RA synovial fibroblasts measured by WST-8 assay after 24 h of stimulation of MTX (1 pM to 1 ÎźM). MTX (1 and 10 nM) significantly decreased cell viability as shown in Fig. 1, while 1â100 pM of MTX did not. (PDF 274 kb