Schematic diagram showing the course of CRS inducing abnormal activation of primordial follicles.

Abstract

<p>CRS leads to the excessive activation of primordial follicles, accompanied by up-regulated expression of Kitl and its receptor Kit, and the activation of PI3K/PTEN/Akt pathway. What is more, the level of serum AMH was increased significantly after CRS. CRH induced by chronic stress might play an important role in the activation and exhaustion of primordial follicles. CRS, Chronic restraint stress.</p