At clinically relevant concentrations the anaesthetic/amnesic thiopental but not the anticonvulsant phenobarbital interferes with hippocampal sharp wave-ripple complexes-1
<p><b>Copyright information:</b></p><p>Taken from "At clinically relevant concentrations the anaesthetic/amnesic thiopental but not the anticonvulsant phenobarbital interferes with hippocampal sharp wave-ripple complexes"</p><p>http://www.biomedcentral.com/1471-2202/8/60</p><p>BMC Neuroscience 2007;8():60-60.</p><p>Published online 31 Jul 2007</p><p>PMCID:PMC1950312.</p><p></p>r (b). The dotted line in "a" marks the temperature of 32°C. In "b", the three representative temperatures (32°C, 27°C and 37°C) are indicated for purpose of comparison. During the increase of the temperature from 34–35°C to higher values, the histogram of the period bifurcated. This deviation of the values was due to the fact that SPWs were frequently generated in a burst-like fashion (shown in B), where consecutive waves appeared at short intervals, whereas at the same time the period between bursts of events increased. . Continuous recording of SPW-R complexes (left column) and power spectra at the high frequency range (right column) obtained at different temperatures. Single ripple episodes (band-pass filtered traces) are shown as inserts in spectral plots; calibration bars: 10 μV, 10 ms. At 37°C SPWs appeared frequently as bursts of several events. Ripple frequency changed monotonically with temperature. Note that at 37°C ripple frequency exceeded 200 Hz. Data in "A" an "B" were collected from two different slices. . Collective date of the period of SPWs and of the frequency of ripple oscillation at three different temperatures. Asterisks indicate significant differences with reference to the group of 32°C (paired t-test, at < 0.05, n = 4)
