MOZ-TIF2 repression of nuclear receptor-mediated transcription requires multiple domains in MOZ and in the CID domain of TIF2-4

Abstract

<p><b>Copyright information:</b></p><p>Taken from "MOZ-TIF2 repression of nuclear receptor-mediated transcription requires multiple domains in MOZ and in the CID domain of TIF2"</p><p>http://www.molecular-cancer.com/content/6/1/51</p><p>Molecular Cancer 2007;6():51-51.</p><p>Published online 13 Aug 2007</p><p>PMCID:PMC2048977.</p><p></p>erase activity was measured as described after incubation of the transfected cells for 36 hours of cells with 50 nM estradiol. . The forced expression of CBP does not antagonize MOZ-TIF2 inhibition of ER-mediated transcription. . The inhibition of ER-mediated transcription by MOZ-TIF2 was partially released by increased expression of wild type of TIF2. Open bars, the presence of 50 nM estradiol; dark bars, without estradiol. Double stars represent a significant difference at P < 0.01 by the two tailed Student T- test compared to the transfection with MOZ-TIF2 in the ligand added condition. Dark circles represent a significant difference at P < 0.05 compared to the transfection with TIF2 alone in the ligand added condition. The numbers on top of the open bars indicate the ratio of light units as described in Figure 3

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