<p><b>Copyright information:</b></p><p>Taken from "Merr. suppresses the induction and progression of autoimmune arthritis by modulating immune response to heat-shock protein 65"</p><p>http://arthritis-research.com/content/9/4/R70</p><p>Arthritis Research & Therapy 2007;9(4):R70-R70.</p><p>Published online 23 Jul 2007</p><p>PMCID:PMC2206370.</p><p></p> LEW rats (= 7 per group) were fed by gavage daily either Celastrus (triangles; 3 g/kg body weight, experimental group) or water (circles; control group) starting on day 4 prior to H37Ra (Mtb) immunization (1 mg/rat) and then continuing throughout the observation period. Following Mtb injection, these rats were scored regularly for signs of arthritis. The difference in the mean arthritic scores of the Celastrus-fed and Water-fed rats during the course of AA was significant (*< 0.05 by Wilcoxon rank sum test). The results of an independent repeat experiment including two groups of Celastrus-treated rats are shown in this section. The difference in arthritic scores of Celastrus-fed versus Water-fed rats was significant (*< 0.05) for each of the groups tested (triangles; 1.5 g/kg, = 4; squares, 3 g/kg, = 4). The photograph shows the hind paw of a representative LEW rat from the water-fed (left) and Celastrus-fed (middle) groups on day 16 after Mtb immunization. The hind paw of a naive LEW rat (right) is also shown for comparison; each unit on the scale equals 1 mm, with 10 units between numbered marks
