Control group, (B) S group, (C) As group, (D) ATRA group, (E)S/ATRA group and (F) As/ATRA group. Arrows indicate positive cells. Scale bar = 50 μm. The average Integrated Optical Density (IOD) of each group was performed by a computer-assisted quantitation. (G) IOD data is shown as the mean ± SE (n = 10). The average IODs in As-ODN and ATRA treated groups were significantly increased as compared to S-ODN group and control group. * < 0.01, one-way ANOVA. Significant interaction was observed between As-ODN and ATRA treatment. * * F = 45.918, < 0.01, two-way ANOVA. (H) Electron microscopy showed typical feature of apoptotic cell in As-ODN and ATRA treatment groups. Whereas, no ultrastructural changes were observed in S-ODN group and control group (data not shown).<p><b>Copyright information:</b></p><p>Taken from "Antisense oligonucleotides and all-trans retinoic acid have a synergistic anti-tumor effect on oral squamous cell carcinoma"</p><p>http://www.biomedcentral.com/1471-2407/8/159</p><p>BMC Cancer 2008;8():159-159.</p><p>Published online 3 Jun 2008</p><p>PMCID:PMC2427037.</p><p></p
