(A) Network of neurons in mixed hippocampal cultures visualized by Alexa Fluor 594–conjugated Cholera toxin B subunit that binds to ganglioside GM1 on neuronal membrane. (B) TTX (10 nM) sensitive Ca oscillations in a group of neurons. Bath application of 10 μM CNQX (C), 10 μM APV (D), or 1 μM nimodipine inhibited the SCO. For clarity, the data shown in B–D are for five neurons in a field from a typical experiment repeated three to five times. Data in D are mean ± SEM for 30 neurons from three experiments (*, P < 0.005). The controls were taken as SCO in each experiment before drug treatment.<p><b>Copyright information:</b></p><p>Taken from "Nitric Oxide–mediated Modulation of Synaptic Activity by Astrocytic P2Y Receptors"</p><p></p><p>The Journal of General Physiology 2008;132(3):339-349.</p><p>Published online Jan 2008</p><p>PMCID:PMC2518726.</p><p></p
