Synthesis of δ-Carbolines via a Pd-Catalyzed Sequential Reaction from 2-Iodoanilines and <i>N</i>-Tosyl-enynamines

Abstract

A facile Pd-catalyzed sequential reaction has been developed for the synthesis of δ-carbolines from 2-iodoanilines and <i>N</i>-tosyl-enynamines. This protocol involves Larock heteroannulation/elimination/electrocyclization/oxidative aromatization cascade sequences and allows access to multisubstituted δ-carbolines in moderate to good yields