Mda-9/syntenin expression in a pseudo-metastatic model of uveal melanoma obtained by injection of human 92.1 cells under the spleen capsule of NOG mice: mda-9/syntenin expression is higher in liver metastases than in spleen.

Abstract

<p><b>A:</b> Immunohistochemistry of murine splenic uveal melanoma and liver metastases (Original Magnification 400×). Arrows indicate single cells of uveal melanoma strongly positive for mda-9/syntenin present in the spleen; arrowheads indicate mda-9/syntenin positive metastatic cells in the liver. <b>B:</b> Flow-cytometric analysis of intracellular mda-9/syntenin expression in permeabilized 92.1 cell derived from splenic tumor and liver metastases, C- is the negative control.</p