Effects of statin therapy on cancer incidence in each study.

Abstract

<p>In the left panel, unweighted rate ratios (RRs) are plotted for each trial of the comparison of first event rates between randomly allocated treatment groups, along with their 99% confidence intervals (CIs). Trials are ordered according to the absolute reduction in LDL cholesterol at 1 year within each type of trial comparison (statin versus control and more versus less statin). In the right panel, rate ratios are weighted per 1 mmol/L LDL cholesterol difference at 1 year. Totals and subtotals, together with their 95% CIs, are indicated by open diamonds.</p