The Markov model state transition diagram built from the 15 effective drug delivery trials.

Abstract

<p>The “start” and “end” states are added for illustrative purposes. In the effective delivery strategy, it is possible to transition between three states. From the high drug state it is only possible to remain in that state, or transition to the medium drug state. Similarly, once in the medium drug state it is not possible to transition back to the high drug state, it is only possible to remain in that state or transition to the low drug state. Once in the low drug state, the system will remain in the state for various iterations before finally ending.</p