Kimograph for a simulation of the full, spatially distributed, chemotaxis system.

Abstract

<p>In the simulation, before starting to stimulate cells with a uniform concentration of cAMP, the system is left to relax with zero signal until the levels of the relevant factors become stationary. Then, the stimulation is switched on at time , when we also impose a gaussian noise on the uniform concentration background in order to mimick random inhomogeneities. We compare the experimental results reported in Reference <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0030977#pone.0030977-Postma1" target="_blank">[19]</a> with the simulations of model (1–8). The kimograph shows the time evolution of simulated PIP3 levels along the major cell perimeter. Time in the simulation is to be compared with time s in the experiment.</p