Schematic overview of most differentially expressed modules identification.

Abstract

<p>Identifying the most differentially expressed modules include three key steps. First, the GO co-expressed network is constructed by combined the protein-protein interaction network, which was from the HPRD and BioGRID database, and GO gene sets together. The edges of network were weighed by co-expression level between their corresponding linked nodes. Second, functional modules were identified by the weighted Girvan-Newman algorithm <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0033653#pone.0033653-Newman1" target="_blank">[32]</a>. Finally, functional modules were ranked on their differential levels between recurrent and non-recurrent tumors which were evaluated by the p-SAGE algorithm <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0033653#pone.0033653-Huang1" target="_blank">[38]</a>.</p