<p>A. The firing rate of the model neuron increases as a function of temperature for DC = 0.5, 1, 1.5 and 2×10<sup>−2</sup> pA/µm<sup>2</sup> (500 ms duration) respectively. B. The total sodium charge entering during one action potential decreases exponentially as a function of temperature for DC = 0.5, 1, 1.5 and 2×10<sup>−2</sup> pA/µm<sup>2</sup>, respectively. C. For the conditions in the above four DC inputs, the total sodium charge (sodium charge per spike times the firing rate) for a given DC signal as a function of temperature. Note that the total Na<sup>+</sup> entry reaches a minimum at a temperature of between 37–42°C. D. The firing rate increases as a function of temperature for the normal situation (black), and when τ<sub>m</sub> (green), τ<sub>h</sub> (red) and τ<sub>n</sub>(blue) are kept invariant. Notice that the I<sub>K</sub> activation time constant τ<sub>n</sub> is the key factor controlling the firing rate change as a function of temperature. E. For the above four situations, the total Na<sup>+</sup> charge per single spike as a function of temperature. Notice that I<sub>Na</sub> inactivation time constant τ<sub>h</sub> is the key factor controlling the total Na<sup>+</sup> charge per spike as a function of temperature. F. For the above four situations, the total Na<sup>+</sup> charge per DC input (nC/cm<sup>2</sup>) as a function of temperature. Note that the total Na<sup>+</sup> entry does not go through a global minimum for both test groups with temperature-independent τ<sub>h</sub> and τ<sub>n</sub>.</p
