Summary of structure of mathematical model.

Abstract

<p><b>A</b> shows the basic model unit with parasite life cycle stages in the human host, antimalarial drug action and immunity. <b>B</b> shows the unit in <b>A</b> repeated three times to track parasites resistant to artemisinins and ACT partner drug. <b>C</b> shows multiple repetitions of <b>B</b> to reproduce the various strategies used in the trial. In A, ‘blood stage’ refers to individuals with asexual stage parasites in the peripheral blood but no gametocytes and ‘infectious stage’ is individuals with gametocytes.</p