Quercetin and allopurinol restore streptozotocin (STZ)-induced hyperuricemia and kidney dysfunction in rats.

Abstract

<p>Biochemical analyses showed uric acid (A-C), creatinine (D-F) and urea nitrogen (G-I) levels in serum and urine, as well as their clearance rates at 7 weeks after STZ injection in different groups of rats as indicated. The data are expressed as the means ± SEM (n = 8). ⁺⁺⁺<i>P</i><0.001 <i>versus</i> normal control; *<i>P</i><0.05, **<i>P</i><0.01, ***<i>P</i><0.001 <i>versus</i> STZ control.</p