Summary diagram of alteration of hematopoiesis, UPR signaling and apoptosis in <i>Grp78</i> conditional knockout in the hematopoietic system.

Abstract

<p>GRP78 depletion in the hematopoietic system leads to altered hematopoiesis, activated UPR signaling and enhanced apoptosis. Open arrows represent an increased level and closed arrows represent a decreased level.</p